Comparison of Serum Vitamin D and Interleukin-6 Levels in Patients with Preeclampsia and Healthy Pregnant Women

Authors

  • Bahrehmand, Fariborz Department of Clinical Biochemistry, Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Dinarvand , Gholamabass Department of Biochemistry, Faculty member of Abadan School of Medical Sciences, Abadan, Iran
  • Rezavand, Negin Department of Obstetrics and Gynecology, Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Vaisi, Firozeh Department of Obstetrics and Gynecology, Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Hoshiar , Azin Department of Obstetrics and Gynecology, Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Kiani, Amir Department of Pharmacology and Toxicology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Vaisi-Raygani, Asad Professor of Clinical Biochemistry, Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Zangneh , Maryam Department of Obstetrics and Gynecology, Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract:

ABSTRACT &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Background and Objective: Nutritional factors and activation of inflammatory pathways are thought to be involved in pathogenesis of preeclampsia in pregnant women. The present study aimed to compare the serum levels of vitamin D and interleukin-6 in healthy pregnant women with those of preeclampsia ones. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Methods: This case-control study was performed on 120 healthy pregnant women and 120 women with preeclampsia referred to Imam Reza Hospital in Kermanshah. The serum levels of vitamin D and IL-6 were measured by ELISA method. The data was analyzed by SPSS software (version 20) using independent t-test, the P-value of <0.05 was considered as statistically significant. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Results: There was no statistically significant difference between the mean level of vitamin D in the patients (37.64 &plusmn; 29.50 ng/ml) and the controls (40.06 &plusmn; 33.20 ng/ml). the serum level of IL-6 in patients with preeclampsia (21.71 &plusmn; 32.24 pg/ml) was significantly higher compared to that of&nbsp; control group (15.04 &plusmn; 28.6 pg/ml) (P <0.001). &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Conclusion: Based on the findings of this study, inflammatory factors and cytokines such as IL-6 can be considered as risk factor for preeclampsia. However, more studies with larger sample sizes are required to further evaluate the association of vitamin D levels and risk of preeclampsia. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Keywords: Pregnancy, Pre-Eclampsia, Vitamin D, Interleukin-6.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Comparison of Serum Levels of Vitamin D in Nulliparous Women with Severe Preeclampsia with Healthy Pregnant Woman

Background and Objectives: Hypertensive disorders are one of the causes of morbidity and mortality, which occur in 5% of pregnancies. One of the causes of preeclampsia, is inappropriate regulation of activator of placental Cyp27B1 enzyme, which is induced by vitamin D deficiency. This study aimed to assess the relationship between the level of vitamin D with risk of preeclampsia in pregnant wom...

full text

Comparison of Vitamin D levels in cases with preeclampsia, eclampsia and healthy pregnant women.

The aim of this study is to assess vitamin D levels in eclampsia, preeclampsia and healthy pregnant women and the role of vitamin D deficiency in the etiology of preeclampsia (PE). Forty healthy pregnant women, 83 preeclamptic and 32 eclamptic pregnant women were included. Maternal and infant medical records were reviewed. Blood samples were obtained from all groups. Demographics and serum vita...

full text

Comparison of serum interleukin-8 levels in patients with recurrent aphthous stomatitis and healthy individuals

Comparison of serum interleukin-8 levels in patients with recurrent aphthous stomatitis and healthy individuals Dr. HR. Abdolsamadi* - Dr. Sh. Kasraie** * Assistant Professor of Oral Medicine Dept., Faculty of Dentistry, Hamadan University of Medical Sciences. ** Assistant Professor of Operative Dentistry Dept., Faculty of Dentistry, Hamadan University of Medical Sciences. Background and Aim: R...

full text

A comparison between serum levels of interleukin-6 and CA125 in patients with endometriosis and normal women

Background: The purpose of the present study was to compare the serum levels of IL6 and CA125 in women with and without endometriosis. They were also compared in mild, moderate and severe cases. Methods: In this case-control study, CA125 and IL6 levels in 76 women with laparoscopic proven endometriosis were compared with 76 women without evidence of endometriosis. Sensitivity, specificity, p...

full text

Comparison of serum vitamin D levels in elderly patients with and without Covid-19

Background and purpose: due to the occurrence of covid-19 disease in the world and the lack of standard treatment for this disease, a lot of research was done to find the causes of the disease and the methods of treatment. and is not infected with covid 19. Materials and methods: This study is a case-control study and its statistical population was elderly people who referred to Bandargaz city...

full text

comparison of serum levels of vitamin d and inflammatory markers between women with gestational diabetes mellitus and healthy pregnant control

objective: vitamin d appears to be involved in regulation of glycemic and inflammatory responses in gestational diabetes. the purpose of this study was to compare the serum levels of 25-hydroxyvitamin d (25(oh)d), inflammatory biomarkers and glycemic profile between gestational diabetes mellitus (gdm) and normal glucose tolerance (ngt) pregnant women. materials and methods: in this cross-sectio...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 10  issue 4

pages  12- 17

publication date 2016-09

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023